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Principles and functions of drug release from microporous film-coated tablets

Issuing time:2024-05-28 10:14

Microporous membrane-coated tablets are a thin layer of microporous film wrapped on the surface of drug particles or tablet cores. They are oral solid pharmaceuticals or health food particles. This kind of microporous film is used to add microporous films to the surface of tablets. The technology, called film coating, is a process of applying a thin layer of film-forming material to the surface of the tablet core. The choice of additive process for film coating depends on the desired coating thickness, tablet size, production scale and equipment. Availability and other factors.

Polyamide pure membrane, Polyether pure membrane

Commonly used microporous film coating production technologies include pot coating, which means placing the tablet core in a rotating disk or drum coater, and using a spray gun or nozzle system to spray the film-forming material onto the tablet, because the film material contains A polymer solution or suspension that requires polymers, plasticizers, colorants and other additives is sprayed onto the tablets, and each layer is dried before the next layer is applied; another technology is fluidized bed coating, in which It is a common technology in large-scale production. The tablet core is placed in a fluidized bed coating machine and fluidized by the air flow. A spray gun or atomizer is used to spray the film-forming material onto the fluidized tablet, thereby coating the tablet. A film coating is formed on the surface of the agent.

Polyacrylonitrile pure membrane, Silica gel pure membrane

The drug release principle of microporous film-coated tablets is the controlled diffusion of active ingredients through the microporous film coating. The main function of the film coating is to provide a barrier and regulate the release of the drug from the tablet core within a specific time. Due to the membrane The material is composed of a polymer with a network of micropores or channels that enable drug molecules to diffuse from the tablet core into the surrounding environment or gastrointestinal fluid. The size, density and distribution of the micropores are carefully designed to ensure that the active ingredient A release profile that is consistent with drug diffusion, such as sustained or extended release cycles over time, is beneficial for drugs that require a specific release pattern. Depending on the formulation, coating materials, and expected release characteristics of a specific pharmaceutical agent, different polymers, pore structures, and coating technologies can be used to achieve customized drug release profiles, such as immediate release mode, delayed release mode, extended release, or pulse. Release mode and more.

From the above analysis, we can summarize the main functions of microporous film-coated film materials:

1. The function of controlled release is to control and sustain the release of active ingredients in tablets, adjust the release rate of the drug, and ensure the required release curve to achieve the best therapeutic effect.

2. Protection. The film coating can act as a barrier to the drug, protecting the tablet core from moisture, light, air and other environmental factors that may degrade the drug or affect its stability.

3. Improve appearance. Microporous film coating provides a smooth and shiny surface for tablets, enhancing their visual appeal, which may be more effective in patient acceptance and compliance.

4. The role of masking taste and odor. Some drugs may have unpleasant taste or odor, which can be masked by microporous film coating. The film coating acts as a physical barrier between the drug and taste buds, minimizing ingestion. Any unpleasant sensory experience during the entry process.

Polyvinyl alcohol pure membrane, Polybenzimidazole pure membrane

In short, microporous film-coated tablets play a vital role in ensuring controlled release, protecting drugs, improving appearance and improving patient compliance. They can also help improve the efficacy, stability and overall quality of drugs. Therefore, They are widely used in pharmaceutical and healthcare industries.

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