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What kind of filter membrane should be used to remove white blood cells? What are the requirements f

Issuing time:2023-05-15 13:55

Leukocyte filter membrane are primarily used to remove white blood cells (leukocytes) from blood products such as packed red blood cells or packed platelets. This process, known as leukopenia, has several clinical benefits, such as reducing the risk of certain blood transfusion-related complications, and is used in medical applications such as cardiopulmonary bypass, hemodialysis, and blood transfusion to prevent adverse reactions such as allergic reactions and immune reactions. Requirements for leukocyte filter membrane include appropriate pore size, material, and biocompatibility.
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The pore size requirements of the filter membrane
The principle of the leukocyte filter relies on size exclusion and depth filtration. The membrane pores are designed to be smaller than white blood cells, which allows other blood components such as red blood cells, platelets and plasma to pass through while trapping larger white blood cells. Depth filtration further enhances leukocyte removal by retaining leukocytes within the membrane structure. For effective leukocyte removal, the pore size of the membrane should be smaller than the size of the cells to be filtered. White blood cells are usually about 6-20 microns in diameter. Therefore, filter membrane with a pore size in the range of 3-8 microns are generally suitable for leukocyte removal.
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Filter membrane material requirements
The material of the leukocyte filter membrane should have certain biocompatibility and chemical stability, be able to withstand high pressure and high flow rate of blood, and at the same time not produce severe blood cell rupture, thrombosis and other adverse reactions.
Biocompatibility means that the interaction of a material with an organism will not elicit an immune or other deleterious response. If the leukocyte filter membrane is not biocompatible, it will cause the rupture of leukocytes, platelets, red blood cells and other components in the blood, resulting in adverse reactions such as thrombosis, bleeding, and infection. Chemical stability means that the material will not decompose or chemically react when exposed to drugs or other chemicals. If the leukocyte filter membrane is not chemically stable, it will cause the components in the blood to be decomposed or oxidized, resulting in adverse reactions such as blood coagulation and physiological dysfunction. In short, the pore size and material of leukocyte filtration membrane are important factors affecting its filtration efficiency and safety, which need to be selected and designed according to specific application scenarios.
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What are the commonly used leukocyte filter membrane materials
Commonly used materials for leukocyte filter membranes are polyurethane, polypropylene and polyester. Polyurethane film material has good strength and elasticity, and has excellent wear resistance and oil resistance. Among leukocyte filtration membranes, polyurethane membranes can provide good mechanical strength and durability, and are suitable for high-pressure and high-flow blood filtration. However, polyurethane membranes have low biocompatibility and may cause adverse reactions such as immune response and thrombosis. Polypropylene membrane material also has good chemical stability and biocompatibility, and has certain rigidity and strength. Among leukocyte filtration membranes, polypropylene membranes can provide good filtration efficiency and biocompatibility, and are suitable for medical applications such as extracorporeal circulation, hemodialysis, and blood transfusion. However, polypropylene films are less durable and susceptible to chemicals and UV rays. Polyester film materials have excellent physical properties, such as high strength, high stiffness, and high heat resistance, as well as good chemical stability and transparency. Among leukocyte filtration membranes, polyester membranes can provide high-efficiency filtration and good chemical stability, and are suitable for high-pressure and high-flow blood filtration. However, polyester membranes have low biocompatibility and may cause adverse reactions such as immune reactions and thrombosis.
These materials all have suitable mechanical strength, chemical resistance and biocompatibility. The selection of materials must depend on the specific application and filtration requirements. Health and life are the highest. It is necessary to conduct in-depth research with relevant medical professionals in order to select a more suitable membrane material according to actual needs.

Citation

1. Kuschner, R. E., & Shaffer, T.H. (2003). Evaluation of leukocyte depletion filters for neonatal extracorporealmembrane oxygenation circuits. ASAIO Journal (American Society for ArtificialInternal Organs: 1992), 49(4), 428 -432.

2. Lutz, J., Menke, J., Sollinger, D.,Schinzel, H., & Thürmel, K. (2004). Leukocyte depletion filters in cardiacsurgery: effects on cytokine and complement activation. Perfusion, 19(3 ),177-183.

3. Ishikawa, Y., Sugimoto, T., Morita,Y., & Miyata, Y. (2002). The efficacy of leukocyte removal filters inreducing the incidence of deep sternal wound infection after cardiac surgery.Journal of Thoracic and Cardiovascular Surgery, 123(4), 800-805.

4.Kuntscher, M. V., Germann, G., &Küntscher, L. (2005). Leukocyte depletion filters in trauma patients: effectson blood loss and transfusion volume. Journal of Trauma and Acute Care Surgery,58(6), 1265- 1270.

5. Koc, M., Ozdemir, N., Ertugrul, M.B., & Ozenc, A. (2004). The effect of leukocyte depletion filters on bloodtransfusion requirements and clinical outcomes in patients undergoing coronaryartery bypass graft surgery. Perfusion, 1 9 (2), 123-129.

6. Takagi, H., Manabe, H., Kawai, N.,Goto, S. N., Umemoto, T., & ALICE (All-Literature Investigation ofCardiovascular Evidence) Group. (2010). Leukocyte-reduction filter in cardiacsurgery : a meta-analysis of randomized controlled trials. Interactivecardiovascular and thoracic surgery, 11(1), 70-76.


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